CDC Report Shows People with Monkeypox Have Higher Than Expected Rates of HIV & STIs

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The current outbreak of monkeypox, caused by the monkeypox virus belonging to the same family of viruses as the smallpox virus, has a high incidence rate among persons who are gay and bisexual and other men who have sex with men (MSM).

Previous outbreaks of the disease in Nigeria showed associations between HIV infections and poor clinical outcomes during concurrent monkeypox infections. This highlights the need to understand the association of HIV and other STIs with the clinical outcomes of monkeypox so that public health decisions regarding vaccination and treatment can prioritize the high-risk groups.

About the study

The present study used surveillance data for HIV, monkeypox, and other STIs from eight jurisdictions of the United States to analyze and correlate HIV infection and STI diagnoses within the preceding year to individuals with monkeypox infections. The data were also used to assess the severity of monkeypox cases related to HIV infection status.

The prevalence of HIV infections among persons diagnosed with monkeypox was calculated. The HIV surveillance data was also used to determine the patient's HIV care status, antiretroviral therapy use, the time of diagnosis, and the most recent CD4 count, which indicates the strength of the immune system.

The STI surveillance data were analyzed to record diagnoses of chlamydia, syphilis, and gonorrhea within the last 12 months in persons with monkeypox infection. The symptoms and clinical outcomes of monkeypox in the infected persons were also correlated with the HIV infection status.


The study found that HIV prevalence was 38% among the 1,969 monkeypox patients diagnosed between May 17 and July 22, 2022. The prevalence of one or more reportable STIs among the diagnosed monkeypox patients was 41%. The percentage of monkeypox-infected persons with HIV and one or more STIs diagnosed in the preceding year was 18. 

The incidence of hospitalization with monkeypox was higher among persons with HIV infection (8%) compared to persons without HIV (3%). Among the monkeypox patients with diagnosed HIV infections, 82% showed indications of viral suppression, 92% had received HIV care in the previous year, and 78% showed CD4 counts of 350 per microliter or higher.

The prevalence of HIV in monkeypox patients varied according to demographic factors. Individuals between 18 and 24 had a lower HIV incidence than those aged 55 or above. Race and ethnicity were also factors in varying the prevalence of HIV among monkeypox patients. African American MSM had the highest prevalence (63%), followed by Hispanic persons (41%), non-Hispanic White persons (28%), and non-Hispanic Asians (22%).

Additionally, some monkeypox symptoms, such as rectal pain and bleeding, tenesmus, proctitis, and bloody stools, were reported more by patients with HIV infection than those without HIV. Unsuppressed HIV load in monkeypox patients was also associated with symptoms such as lymphadenopathy, pruritis, rectal bleeding, and bloody stools. Low CD4 levels (<350 per microliter) in monkeypox patients with concurrent HIV infection were linked to a higher incidence of fever and generalized pruritis.

Furthermore, while the national estimate of eligible people who received a prescription for HIV pre-exposure prophylaxis (PrEP) was 25%, the authors report that almost two third of the monkeypox patients without HIV coinfection reported HIV PrEP use. 


Overall, the study indicates a prevalence of HIV infections and recently diagnosed STIs among individuals with monkeypox infections. The prevalence of monkeypox also appears to be higher among MSM, who have higher HIV and STI infection incidences than the general population. Moreover, HIV coinfection in monkeypox patients also shows a higher incidence rate among African American MSM, Hispanic MSM, and MSM older than 55.

According to the authors, the co-occurrence of monkeypox cases with STI diagnoses in the preceding year indicates a possible bias that persons with known HIV infections or STIs might be more likely to approach sexual health care providers when they develop monkeypox symptoms. Likewise, HIV and sexual health care providers might recognize monkeypox symptoms and test for the virus, compared to health care providers not experienced in HIV and STI care.

In conclusion, the results suggest that the transmittance of monkeypox might be linked to persons with HIV infection, indicating the importance of prioritizing monkeypox vaccination for individuals with diagnosed HIV infection and STIs. The authors recommend routine HIV and STI screening and improved access to HIV care and PrEP for persons evaluated for monkeypox. Regular surveillance and matching of monkeypox cases with HIV and STI diagnoses can help establish effective public health measures and interventions against monkeypox.

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