Clarifying the Value of Anti-EGFR Therapy in Metastatic Colorectal Cancer

Clarifying the Value of Anti-EGFR Therapy in Metastatic Colorectal Cancer

Clarifying the Value of Anti-EGFR Therapy in Metastatic Colorectal Cancer

Experts break down the new standard of care for patients with BRAF V600E mCRC and address the global challenges of this complex treatment landscape.

Available credits: 0.25

Time to complete: 15 minutes


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  • Overview

    Even with the recent advances in therapeutic options for patients with BRAF V600E-mutated metastatic colorectal cancer (mCRC), they still have an uphill climb ahead of them.

    How will the new standard of care in the second-line setting address global challenges and unmet needs regarding molecular profiling and treatment sequencing options?

    Join us as 3 experts, Dr. Scott Kopetz, Dr. Elizabeth Smyth, and Dr. Elena Elez, untangle these new advances in treatment and offer their insights on how diagnostic testing can improve patient outcomes.

  • Disclosure of Conflicts of Interest

    In accordance with the ACCME Standards for Integrity and Independence, Global Learning Collaborative (GLC) requires that individuals in a position to control the content of an educational activity disclose all relevant financial relationships with any ineligible company. GLC mitigates all conflicts of interest to ensure independence, objectivity, balance, and scientific rigor in all its educational programs.

    Scott Kopetz, MD, PhD
    Department of Gastrointestinal Medical Oncology
    The University of Texas MD Anderson Cancer Center
    Houston, TX

    Consulting Fees: AstraZeneca/Medinfo, Boehringer Ingelheim, Boston Biomedical, EMD Serono, Genentech, Holy Stone, Lilly, Merck, Novartis

    Elena Elez, MD, PhD
    Medical Oncology Department
    Vall d’Hebron Institute of Oncology (VHIO)
    Barcelona, Spain

    Research: AbbVie, Amgen, AstraZeneca, Bristol, Merck, MSD, Novartis, Pierre Fabre, Roche, Sanofi
    Consulting Fees: Amgen, Bayer, Bristol Myers, Merck, Roche, Sanofi, Servier  

    Elizabeth Smyth, MD
    Clinical Consultant, Department of Oncology
    Cambridge University Hospitals NHS Foundation Trust
    Cambridge, United Kingdom

    Consulting Fees: Astellas Pharma, AstraZeneca, Bristol Myers Squibb, Merck KGaA, Servier

    Reviewers/Content Planners/Authors:

    • Jorge Bacigalupo has nothing to disclose.
    • Cindy Davidson has nothing to disclose.
    • Ann Early has nothing to disclose.
    • Nicole Fox, DNP, MSN-Ed, RN, OCN, has nothing to disclose.
    • Anna Trentini has nothing to disclose.
  • Learning Objectives

    After participating in this educational activity, participants should be better able to:

    1. Formulate strategies to integrate the new standard of care for metastatic colorectal cancer into the clinic
    2. Describe patient selection strategies for BRAF V600E-mutated metastatic colorectal cancer
  • Target Audience

    This activity is designed to meet the educational needs of medical oncologists, pathologists, and other healthcare professionals treating patients with colorectal cancer in Asia Pacific and Europe.

  • Accreditation and Credit Designation Statements

    In support of improving patient care, Global Learning Collaborative (GLC) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC) to provide continuing education for the healthcare team.

    The American Medical Association has an agreement of mutual recognition of Continuing Medical Education (CME) credits with the European Union of Medical Specialists (UEMS), the accreditation body for European countries. Physicians interested in converting AMA PRA Category 1 CreditsTM to UEMS-European Accreditation Council for Continuing Medical Education CME credits (ECMECs) should contact the UEMS at

    Global Learning Collaborative (GLC) designates this enduring activity for a maximum of .25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Global Learning Collaborative (GLC) designates this activity for 15 minutes of nursing contact hours. Nurses should claim only the credit commensurate with the extent of their participation in the activity.

  • Provider(s)/Educational Partner(s)

    AGILE - Academy for Interprofessional Learning and Education - designs, develops, and delivers education across a broad spectrum of diseases and clinical conditions. Our mission is to serve as a trusted source of clinical information that helps healthcare professionals improve competence, performance, and patient outcomes.

  • Commercial Support

    This activity is supported by an independent educational grant from Merck KGaA, Darmstadt, Germany.

  • Disclaimer

    The views and opinions expressed in this educational activity are those of the faculty and do not necessarily represent the views of GLC and AGILE. This presentation is not intended to define an exclusive course of patient management; the participant should use his/her clinical judgment, knowledge, experience, and diagnostic skills in applying or adopting for professional use any of the information provided herein. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patients’ conditions and possible contraindications or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities. Links to other sites may be provided as additional sources of information. Once you elect to link to a site outside of AGILE you are subject to the terms and conditions of use, including copyright and licensing restriction, of that site.

    Reproduction Prohibited
    Reproduction of this material is not permitted without written permission from the copyright owner.

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