Weight Management and Fertility Preservation in Endometrial Cancer Patients

A newly developed, evidence-based weight management program is poised to transform care for endometrial cancer patients pursuing fertility preservation. This initiative integrates oncologic treatment with reproductive health strategies, offering a standardized protocol that addresses both cancer management and fertility goals.

Endometrial cancer, the sixth most common cancer among women globally, has seen a rise in cases among younger women desiring to maintain fertility. Obesity, a known risk factor for endometrial cancer, also adversely affects fertility outcomes. Studies have shown that overweight and obese patients undergoing fertility-sparing treatments experience lower pregnancy and live birth rates compared to their normal-weight counterparts.

Recognizing the need for a comprehensive approach, researchers have developed a weight management intervention grounded in the Medical Research Council framework and World Health Organization guidelines. The program underwent rigorous validation through a two-round Delphi consultation, achieving a 100% response rate and an expert authority coefficient of 0.83, underscoring its scientific robustness and clinical feasibility.

The intervention comprises six primary, 18 secondary, and 53 tertiary components, encompassing dietary guidance, physical activity recommendations, and behavioral strategies tailored to the unique needs of endometrial cancer patients seeking fertility preservation. By addressing weight management in this context, the program aims to enhance hormonal balance, reduce inflammation, and improve both oncologic and reproductive outcomes.

Midwives are identified as pivotal in implementing this program, given their integral role in women's health care. Equipping midwives with the tools and knowledge to manage weight effectively within oncology and reproductive health settings ensures personalized and comprehensive patient care.

Integrating this weight management protocol into clinical practice holds the promise of improving treatment responses, increasing pregnancy and live birth rates, and standardizing care delivery across various healthcare settings. This holistic approach bridges the gap between cancer care and reproductive health, empowering multidisciplinary teams to optimize patient outcomes.

In conclusion, the development and validation of this structured weight management program represent a significant advancement in the care of endometrial cancer patients seeking fertility preservation. Grounded in internationally recognized guidelines and reinforced by expert consensus, the program offers a replicable model adaptable to diverse healthcare environments. By standardizing care protocols and involving key healthcare professionals, this initiative sets a new benchmark in integrated oncologic and reproductive healthcare.