Evolving Perspectives in PIK3CA-related Overgrowth Spectrum Diagnosis & Treatment

Evolving Perspectives in PIK3CA-related Overgrowth Spectrum Diagnosis & Treatment

Evolving Perspectives in PIK3CA-related Overgrowth Spectrum Diagnosis & Treatment

Don’t miss this essential discussion on the current and emerging strategies for the diagnosis and management of PIK3CA-related overgrowth spectrum.

Available credits: 0.50

Time to complete: 30 minutes


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  • Overview

    PIK3CA-related overgrowth spectrum (PROS) refers to various clinical entities that share the same pathogenetic mechanism. These disorders are caused by somatic gain-of-function PIK3CA mutations. Diagnosis of PROS is often challenging and requires DNA sequencing of the affected tissue. PIK3CA genetic mutations vary greatly depending on the tissue being tested. PROS is not considered an inherited disease.

    The road to a diagnosis of a rare disease can be a long, winding process. Because of its rarity, a wide spectrum of symptoms, and disease heterogeneity, patients may feel alone and as though they are the only ones with the disease. Management of PROS currently involves symptomatic treatment of its manifestations; an unmet need exists for targeted, systemic therapies.

    Currently, there is no cure for PROS. This educational activity will assist the interprofessional care team to better understand, apply, and interpret advances in current and emerging evidence that will help bridge the gap toward faster adoption into patient care.

  • Disclosure of Conflicts of Interest

    AXIS Medical Education requires faculty, instructors, authors, planners, directors, managers, reviewers, and other individuals who are in a position to control the content of this activity to disclose all real or apparent conflicts of interest they may have with ineligible companies.  An ineligible entity is any organization whose primary business is producing, marketing, selling, re-selling, or distributing healthcare products used by or on patients. All relevant conflicts of interest are identified and mitigated prior to initiation of the planning phase for an activity. 

    AXIS has mitigated and disclosed to learners all relevant conflicts of interest disclosed by staff, planners, faculty/authors, peer reviewers, or others in control of content for this activity. Disclosure of a relationship is not intended to suggest or condone bias in any presentation but is made to provide participants with information that might be of potential importance to their evaluation of a presentation or activity. Disclosure information for faculty, authors, course directors, planners, peer reviewers, and/or relevant staff is provided with this activity.

    The faculty reported the following relevant financial relationships or relationships they have with ineligible companies of any amount during the past 24 months:

    Julie Blatt, MD, reported a financial interest/relationship or affiliation in the form of Contracted research: Novartis Pharmaceuticals Corp.

    William Mencia, MD, FACEHP, CHCP reports no financial relationships or relationships to products or devices with any ineligible company of any amount during the past 24 months.

    Taizo Nakano, MD, reported a financial interest/relationship or affiliation in the form of Consultant: Novartis Pharmaceuticals Corp. Advisory board/consulting:Swedish Orphan Biovitrum (Sobi).

    The directors, planners, managers, and reviewers reported the following financial relationships they have with any ineligible company of any amount during the past 24 months: Linda Gracie-King, MS; Jocelyn Timko, BS; Laura Healy, BS; Marilyn L. Haas-Haseman, PhD, RN, CNS, ANP-BC; Adrienne N. Nedved, MPA, PharmD, BCOP; and Melissa Duffy, PA-C hereby state that they do not have any financial relationships or relationships any ineligible company of any amount during the past 24 months.  Robert Mocharnuk, MD, reported a financial interest/relationship or affiliation in the form of Common stock: Merck of any amount during the past 24 months.

  • Target Audience

    This educational activity is designed for primary and specialty providers who are involved in the care of patients with PIK3CA-related overgrowth spectrum (PROS), including pediatricians, primary care clinicians, internal medicine physicians, dermatologists, neurologists, hematologists, oncologists, maternal-fetal physicians, surgeons, pathologists, advanced practitioners and other healthcare professionals who are part of the interprofessional team responsible for the therapeutic management of patients who may have a rare disorder that causes overgrowth of specific parts of the body, due to mutations in the PIK3CA gene, and is grouped under the umbrella term of PROS.

  • Learning Objectives

    At the conclusion of this activity, participants should be better able to:

    1. Summarize the role of the PI3K/AKT/mTOR pathway in cell proliferation that result in rare and complex disorders, and improve awareness of the epidemiology, burden, and need for timely referral of patients with PROS.
    2. Outline difficulties related to obtaining a PROS diagnosis and the psychological and quality of life challenges this often creates for patients and families.
    3. Compare traditional therapeutic approaches for PROS, including treatment goals, with the objectives of current clinical trials assessing the efficacy and safety of novel agents.
    4. Evaluate the clinical efficacy and safety data of current and past clinical trials, review best practices, and improve understanding of how to incorporate emerging treatment options that address the root causes of PROS.
  • Accreditation and Credit Designation Statements

    In support of improving patient care, AXIS Medical Education is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

    This activity was planned by and for the healthcare team, and learners will receive 0.5 Interprofessional Continuing Education (IPCE) credit for learning and change.

    Credit Designation for Physicians
    AXIS Medical Education designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

    Credit Designation for Physician Assistants

    AXIS Medical Education has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.5 AAPA Category 1 CME credits.  Approval is valid until 8/25/2023 PAs should only claim credit commensurate with the extent of their participation.

    Credit Designation for Pharmacists
    This application-based activity is approved for 0.5 contact hours of continuing pharmacy education JA4008106-0000-22-029-H01-P.

    Credit Designation for Nursing
    AXIS Medical Education designates this continuing nursing education activity for 0.5 contact hours.

    Learners are advised that accredited status does not imply endorsement by the provider or ANCC of any commercial products displayed in conjunction with an activity.

  • Disclaimer

    Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

  • Provider(s)/Educational Partner(s)

    Provided by AXIS Medical Education.

  • Commercial Support

    This activity is supported by an educational grant from Novartis Pharmaceuticals Corporation.

  • Method of Participation and Request for Credit

    To receive credit for this activity, participants must review the activity information including learning objectives and faculty/planner disclosures and actively participate in the educational activity. Upon successfully completing the post-test with a score of 75% or better and the post-activity evaluation, your certificate will be made available immediately. For pharmacists, your record will be uploaded to CPE Monitor.

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